Protein Domains
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
What are Protein Domains?
A protein domain is an identifiable or conserved section of a protein that can fold, function, exist independently from the protein structure [4]. A whole functional "protein" is comprised of one or more protein domains that all work together. The protein domains are typically similar in homologous organisms.
What Protein Domains are present in G6PD?
Figure 1. The two domains of G6PD, shown by SMART (top) and Pfam (bottom). G6PD_N refers to the NAD binding domain. G6PD_C refers to the C-terminal domain.
Using online tools, SMART and PFam, I discovered that the G6PD gene has two protein domains: an NAD binding domain (G6PD_N) and a C-terminal domain (G6PD_C). The domain from SMART also shows a low-complexity region (pink). This means that this region could be significant, but has not been confirmed.